Dec 13, 2021 – Huahui Health Ltd. today announced that HH-120, a broad-spectrum neutralizing fusion protein for SARS-CoV-2, showed positive results on the recently emerged Omicron variant.
Back in 2003, Dr. Wenhui Li (founder of Huahui Health) was the first scientist to discover that SARS-CoV infects human cell via the ACE2 receptor. After the outbreak of the COVID-19 pandemic, with years of research and knowledge on coronaviruses and ACE2 protein, Dr. Wenhui Li led the research team and developed HH-120, a broad-spectrum neutralizing fusion protein for all ACE2-dependent coronaviruses. Through binding to the S protein and disrupting the membrane fusion process, HH-120 can directly neutralize the virus and prevent human cells from being infected.
“We have conducted a large number of pre-clinical studies showing that HH-120 has potent neutralization activity against not only all SARS-SoV-2 variants of concern, including the Alpha, Beta, Gamma and Delta variants, but also other coronaviruses such as SARS-CoV and Pangolin-CoV. We have also observed an interesting trend that the more transmissible the virus or variant, the higher the neutralization activity of HH-120,” says Dr. Wenhui Li. “With respect to Omicron, we have lately completed several in vitro studies. The results all suggest that HH-120 remains highly effective against Omicron, despite the large number of mutations on its spike protein. The neutralization activity against Omicron is similar to that against the Delta variant, and higher than against other variants.”
Huahui Health is actively pursuing global clinical development of HH-120. A randomized, double-blinded, placebo-controlled Phase I study is currently ongoing in Australia. So far all preliminary results suggest good safety and tolerability profile of HH-120.
“HH-120 has demonstrated potent broad-spectrum anti-SARS-SoV-2 neutralization activity. Via aerosol inhalation, HH-120 can directly act on viruses throughout the entire respiratory tract including the nose cavity and the lungs, and may potentially lead to more significant relief of symptoms, shortening of symptom duration, viral load drop, and reduction in risks of disease worsening. The local delivery of drug does not cause systemic exposure, and may therefore potentially be well positioned for certain patient population with special safety requirements, such as breast-feeding or pregnant women,” says Dr. Bin Chen, the CEO of Huahui Health. “Considering that SARS-CoV-2 will likely co-exist with mankind for quite some time, the mAb and first-generation oral therapies may not be able to address all the challenges continuously posed by the virus. The novelty of HH-120’s molecular design assures that it will remain highly effective against emerging SARS-CoV-2 variants, and potentially SARS-SoV-3 that may emerge many years in the future. Not only will HH-120 play a unique role in fighting this pandemic, it will also likely become a valuable tool for the next epidemic caused by another ACE2-mediated coronavirus. It is of significant and strategic value in the long term. Huahui Health will expedite the clinical development of this novel asset and join forces with innovators across the globe in the pandemic control efforts.”
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